Sodium-channel blocker toxicity (tricyclic overdose) on a 12-lead ECG

Sinus tachycardia with a QRS over 100 ms and a tall terminal R in aVR (over 3 mm, or R/S over 0.7): the end of the QRS swings right.

What to look for

Tricyclics, and other drugs that block sodium channels, slow conduction through the ventricles, the right side most. The QRS widens past 100 ms and its last part swings right and up, so aVR grows a tall terminal R. Over 100 ms predicts seizures; over 160 ms, ventricular arrhythmias. The anticholinergic effect drives a sinus tachycardia. In an overdose or unexplained coma, a wide QRS with that aVR R is the trigger for sodium bicarbonate under your protocol. Check lead I: its P wave stays upright, which tells you it isn't swapped arm leads.

Examples

Each is a standard 12-lead: 2.5 seconds of each lead in four columns, with 10 seconds of lead II along the bottom, drawn to scale (25 mm a second, 10 mm a millivolt). The measurements are under each one.

Example 1 · 12-lead · 10 seconds
IaVRV1V4IIaVLV2V5IIIaVFV3V6II25 mm/s · 10 mm/mV
Rate
105/min
Rhythm
RegularSinus: upright in II, biphasic in V1, one before every QRS
PR
0.18 s
QRS
0.11 s, narrow
Axis
68°, normal
QTc
0.44 s
ST up
None
ST down
None
T inverted
None (apart from aVR)
Also
Pathological Q waves (40 ms or wider) in aVL
Example 2 · 12-lead · 10 seconds
IaVRV1V4IIaVLV2V5IIIaVFV3V6II25 mm/s · 10 mm/mV
Rate
127/min
Rhythm
RegularSinus: upright in II, biphasic in V1, one before every QRS
PR
0.15 s
QRS
0.14 s, wide
Axis
61°, normal
QTc
0.42 s
ST up
None
ST down
None
T inverted
None (apart from aVR)
Also
Pathological Q waves (40 ms or wider) in aVL

Don't confuse it with

The ECG tool in the app gives you a new 12-lead every time and walks you through reading it: rate, QRS, axis, then where the ST is up and down. It's part of the Paramedic level, and you can try 5 ECGs a day free.

Try the 12-lead drill

Where the criteria come from

Others in the Electrolytes, drugs and temperature group